Association of rare, recurrent nonsynonymous variants in the germline of prostate cancer patients of African ancestry.

ABSTRACT:

Background

Although men of African ancestry (AA) have the highest mortality rate from prostate cancer (PCa), relatively little is known about the germline variants that are associated with PCa risk in AA men. The goal of this study is to systematically evaluate rare, recurrent nonsynonymous variants across the exome for their association with PCa in AA men.

Methods

Whole exome sequencing (WES) of germline DNA in two AA PCa patient cohorts of Johns Hopkins Hospital (N = 960) and Wayne State University (N = 747) was performed. All nonsynonymous variants present in both case cohorts, with a carrier rate between 0.5% and 1%, were identified. Their carrier rates were compared with rates from 8128 African/African American (AFR) control subjects from The Genome Aggregation Database

SUBMITTER: Wei J 

PROVIDER: S-EPMC11908508 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature