Prognostic significance of tumor deposit counts in stage III colorectal cancer based on T/N staging and chemotherapy status: A retrospective cohort study.

ABSTRACT:

Background

We aimed to evaluate the impact of tumor deposit (TD) count on cancer-specific survival (CSS) and disease-free survival (DFS) in stage III colorectal cancer (CRC) patients stratified by T and N staging, and further explore its impact on chemotherapy effect.

Method

We determined the optimal TD cut-off value for stage III CRC patients from the SEER database utilizing X-tile analysis, and retrospectively analyzed the clinicopathological data of 443 patients from the First Affiliated Hospital of Wenzhou Medical University from 2019 to 2020. Chi-square (χ2) tests compared categorical variables. Kaplan-Meier assessed CSS and DFS. Cox regression model evaluated prognostic factors on CSS and DFS.

Results

2TD is the optimal cutoff value for prognosis in Stage III CR

SUBMITTER: Zheng C 

PROVIDER: S-EPMC11908539 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature