Evaluating the alignment of recent cardiac arrest randomized controlled trials with the top resuscitation science knowledge gaps.

ABSTRACT:

Objective

To determine if recently published cardiac arrest randomized controlled trials (RCTs) align with and address the top scientific gaps previously identified in the American Heart Association (AHA) cardiac arrest treatment guidelines.

Methods

All RCTs involving human subjects experiencing non-traumatic cardiac arrest, published between January 1, 2015, and December 31, 2022, were identified through searches in MEDLINE, Embase, and Web of Science. Abstracts or full manuscripts were individually reviewed and categorized according to the themes and rationale for the most urgent knowledge gaps in the 2015 AHA cardiac arrest guidelines published by Panchal et al. The data were analyzed descriptively.

Results

A total of 87 cardiac arrest RCTs were identified over the

SUBMITTER: Coute RA 

PROVIDER: S-EPMC11908540 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature