The risk for psychiatric disorders in offspring from thrombosis-prone pedigrees in Sweden: a nationwide family study.

ABSTRACT:

Background

Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders.

Objectives

We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees.

Methods

This was a Swedish national family study. We identified a total of 482,184 Swedish pedigrees from the Swedish Multigeneration Register containing a mean of 14.2 parents, aunts/uncles, grandparents, and cousins of a core full-sibship that we termed the pedigree offspring (n = 751,060). We then derived 8 empirical classes of these pedigrees based on the density of cases of

SUBMITTER: Zoller B 

PROVIDER: S-EPMC11908565 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature