Green-based anti-biofilm nanoformulations against bacterial contaminations in nosocomial environments.

ABSTRACT: α-amylase enzyme molecules were conjugated to biocompatible and biodegradable ad-hoc synthetized polycaprolactone (PCL) nanoparticles, in order to fabricate an effective and innovative nanoplatform for the treatment of nosocomial Staphylococcus aureus contaminations. Indeed, PCL was chosen as the polymer matrix due to its features and the easy scalability of its synthesis, which enables to obtain a linear or star-shaped architecture with high functionality as in the polymer used. The developed nanoformulation underwent extensive structural and functional characterization to evaluate nanoparticles size and morphology before and after enzyme immobilization. Its antibiofilm effectiveness was then validated against bacterial strains isolated from hospital surfaces, demonstrating

SUBMITTER: Lo Bello G 

PROVIDER: S-EPMC11908580 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature