Analysis of blood migration components in rats treated with Shaoyao Gancao Decoction using UPLC-Q-TOF-MS/MS.

ABSTRACT: To study the prototype components and metabolites at different time points in the serum of rats after oral administration with Shaoyao Gancao Decoction (SGD), and to analyze their metabolism regularities in vivo. The UPLC-Q-TOF-MS/MS method was used to analyze the drug-containing serum samples at different time points. The mass spectrometry data were preliminarily processed using Analyst® TF 1.7.1 Software, followed by advanced analysis and visualization by PeakView 2.0 and Masterview1.0 to determine the retention time and relevant details of prototype components and metabolites. The MetabolitePilot™1.5 was employed to analyze the prototype components and metabolites in drug-containing serum samples at different time points, systematically summarizing their in vivo metabolic profiles. A to

SUBMITTER: Wu L 

PROVIDER: S-EPMC11908583 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature