Optimizing the white light emission in the solid state isatin and thiazole based molecular hybrids by introduction of variety of substituents on isatin and thiazole ring systems.

ABSTRACT: An efficient and practical 3-component reaction strategy has been developed for the synthesis of a series of multi-colour emissive isatin-thiazole based fluorophores, thiazolylhydrazonoindolin-2-ones (4) from readily available isatins (1), thiosemicarbazide (2) and α-bromoketones (3) in the presence of biodegradable citric acid (0.1 N) in ethanol at reflux temperature for 40-60 min. The reaction proceeds via condensation (C[double bond, length as m-dash]N) and subsequent heterocyclization (C-S & C-N) in one-pot. Nature-friendly reaction profile, easy to perform, wide substrate scope, use of non-hazardous solvents/catalysts, good functional group tolerance, excellent yields (91-98%) in short reaction times, scalability and products do not require column chromatography purification ar

SUBMITTER: Shaik S 

PROVIDER: S-EPMC11908639 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature