Assessing genome conservation on pangenome graphs with PanSel.

ABSTRACT:

Motivation

With more and more telomere-to-telomere genomes assembled, pangenomes make it possible to capture the genomic diversity of a species. Because they introduce less biases, pangenomes, represented as graphs, tend to supplant the usual linear representation of a reference genome, augmented with variations. However, this major change requires new tools adapted to this data structure. Among the numerous questions that can be addressed to a pangenome graph is the search for conserved or divergent genes.

Results

In this article, we present a new tool, named PanSel, which computes a conservation score for each segment of the genome, and finds genomic regions that are significantly conserved, or divergent. PanSel can be used on prokaryotes and eukaryotes, with a sequence id

SUBMITTER: Zytnicki M 

PROVIDER: S-EPMC11908644 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature