Diffusion imaging shows microstructural alterations in untreated, non-lesional patients already after a first unprovoked seizure.

ABSTRACT:

Objective

Patients with newly diagnosed epilepsy exhibit brain white matter (WM) abnormalities, but the temporal dynamics of these are unknown. The literature suggests these alterations might be present before diagnosis. This study investigates WM microstructural integrity using diffusion imaging in non-lesional (NL), interictal epileptiform discharge (IED)-free, unmedicated patients who experienced a first unprovoked seizure compared to healthy controls. Furthermore, we evaluated whether the patients who developed epilepsy within a 1-year follow-up had a divergent pattern of WM alterations in contrast to those who did not. We also evaluated patients with established epilepsy.

Methods

We performed a diffusion imaging analysis in a cohort of 82 subjects. Twenty patients recen

SUBMITTER: Segovia-Oropeza M 

PROVIDER: S-EPMC11908665 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature