Immunogenic mapping of potential epitopes from Tc-CTL-1 for the diagnosis of murine toxocariasis.

ABSTRACT:

Background

Toxocariasis is a neglected global zoonosis. The immunological diagnosis has setbacks that hinder further knowledge about its pathology, epidemiology, and public control measures, and lack of financial support and attention prevents innovative research. Although studies on synthetic peptides are common for several infectious pathologies, none evaluated chemically synthetic peptides for toxocariasis diagnosis.

Objective

This study aimed to identify potential synthetic peptides from C-type lectin 1 (Tc-CTL-1) from Toxocara canis.

Methods

In silico analyses were made by five B-cell peptide prediction programs, 3-D modelling, BLASTp homology analysis, and signal-peptide identification. SPOT-synthesis was used for epitope mapping and assessed by dot-blot. Sera f

SUBMITTER: Fonseca GRE 

PROVIDER: S-EPMC11908769 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature