Abnormalities in large-scale brain network dynamics in late-life depression with suicidal ideation: an EEG microstate analysis.

ABSTRACT:

Background

Patients with late-life depression (LLD) with suicidal ideation (SI) often have more explicit suicide plans, and suicide attempts among older adults are more highly lethal than in other age groups. Increasing evidence suggests that people with SI in depression exhibit abnormal brain network connectivity; however, the relationship between suicidal ideation in LLD and brain network dynamics is still unclear.

Methods

We recruited patients with LLD and SI (LLD-SI), patients with LLD without SI (LLD-NSI), and age-matched healthy older adults. We collected 64-channel resting state electroencephalography (EEG) recordings of all participants and used microstate analysis to explore large-scale brain network dynamics.

Results

We included 33 patients with LLD-SI, 29 p

SUBMITTER: Lin Y 

PROVIDER: S-EPMC11908788 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature