Deceased donor kidney function and branched chain amino acid metabolism during ex vivo normothermic perfusion.

ABSTRACT: Current kidney perfusion protocols are not optimized for addressing the ex vivo physiological and metabolic needs of the kidney. Ex vivo normothermic perfusion may be utilized to distinguish high-risk kidneys to determine suitability for transplantation. Here, we assessed the association of tissue metabolic changes with changes in a kidney injury biomarker and functional parameters in eight deceased donor kidneys deemed unsuitable for transplantation during a 12-hour ex vivo normothermic perfusion. The kidneys were grouped into good and poor performers based on blood flow and urine output. The mean age of the deceased kidney donors was 43 years with an average cold ischemia time of 37 hours. Urine output and creatinine clearance progressively increased and peaked at six hours post-perfusio

SUBMITTER: Ahmadi A 

PROVIDER: S-EPMC11908963 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature