Evaluation and Comparison of Laboratory Methods in Diagnosing Mycobacterium tuberculosis and Nontuberculous Mycobacteria in 3012 Sputum Samples.

ABSTRACT: Tuberculosis is a global public health threat as an infectious disease, and effective blocking of transmission relies on timely diagnosis. Although a number of laboratory tests are available in diagnosing Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM), it is still of great need to evaluate their diagnostic value in clinical samples. In this study, we evaluated five MTB diagnostic methods (including conventional sputum smear microscopy, sandwich cup sputum smear microscopy, sputum culture, Xpert-MTB/RIF, and CapitalBio TB/NTM kit detection test) in 3012 sputum specimens and compared their diagnostic performance of the single and combined tests. In the diagnosis of MTB, the Xpert-MTB/RIF had the highest sensitivity, 79.6% (0.770-0.819), among all the single diagnostic

SUBMITTER: Wu Q 

PROVIDER: S-EPMC11908973 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature