First Report of mcr-10 in a Seafood-Borne ESBL-Producing Enterobacter xiangfangensis Strain.

ABSTRACT: mcr-10 is among the growing families of newly identified plasmid-mediated mobile colistin-resistance genes. In this study, we identified an mcr-10 gene in a seafood-borne extended-spectrum β-lactamase (ESBL)-producing Enterobacter xiangfangensis. E. xiangfangensis strain, B12-S77, was subjected to whole genome sequencing using Illumina MiSeq and Oxford Nanopore Technologies. Bioinformatic analysis was performed using tools from the Center for Genomic Epidemiology. The minimum inhibitory concentration (MIC) of 19 antibiotics was determined by the broth microdilution method. Transferability of mcr-10-carrying plasmid was investigated by the conjugation experiment. The strain exhibited a multidrug-resistant (MDR) phenotype against more than three classes of antibiotics but remained susceptibl

SUBMITTER: Xedzro C 

PROVIDER: S-EPMC11909031 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature