Genome-wide association studies of dairy cattle resistance to digital dermatitis recorded at four distinct lactation stages.

ABSTRACT: Digital dermatitis (DD) is an endemic infectious hoof disease causing lameness in dairy cattle. The aim of the present study was to investigate the genetic profile of DD development using phenotypic and genotypic data on 2192 Holstein cows. The feet of each cow were clinically examined four times: pre-calving, shortly after calving, near peak of milk production, and in late lactation. Presence or absence of disease and proportion of healthy feet per cow constituted two DD phenotypes of study. For each phenotype and timepoint of clinical examination, we conducted single-step genome-wide association analyses to identify individual markers and genomic regions linked to DD. We focused on the ten 1-Mb windows that explained the largest proportion of the total genetic variance as well as windows

SUBMITTER: Tarsani E 

PROVIDER: S-EPMC11909109 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature