Maternal excess dietary phosphate intake in the periconceptional period is a potential risk for mineral disorders in offspring mice.

ABSTRACT: Growing consumption of processed foods may cause a greater risk of excessive dietary phosphate intake. The increased dietary phosphate intake as a food additive in the periconceptional period may affect the children's future health. Here, we investigated the effects of maternal excess dietary phosphate intake on offspring in C57BL/6J mice. Female mice were fed a control diet (CP, 0.8% phosphate) or a high-phosphate diet (HP, 1.5% phosphate) for either 21 days during pre-pregnancy or almost 20 days during pregnancy. After weaning, offspring were raised on the CP diet. Relative to the CP groups, offspring from dams fed HP during pre-pregnancy or pregnancy showed decreased urinary phosphate excretion without significant changes in either plasma phosphate level or renal sodium-dependent phosph

SUBMITTER: Hayashi-Suzuki M 

PROVIDER: S-EPMC11909113 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature