Multi-strain carriage and intrahost diversity of <i>Staphylococcus aureus</i> among Indigenous adults in the USA.

ABSTRACT: Staphylococcus aureus (SA) is an opportunistic pathogen and human commensal that is frequently present in the upper respiratory tract, gastrointestinal tract and skin. While SA can cause diseases ranging from minor skin infections to life-threatening bacteraemia, it can also be carried asymptomatically. Indigenous individuals in the Southwest USA experience high rates of invasive SA disease. As carriage is the most significant risk factor for disease, understanding the dynamics of SA carriage, and in particular co-carriage of multiple strains, is important to develop strategies to prevent transmission in vulnerable communities. Here, we investigated SA co-carriage and intrahost evolution by sampling several colonies from multiple anatomical sites and whole-genome sequencing (WGS) on

SUBMITTER: Webb J 

PROVIDER: S-EPMC11909137 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature