Dynamics and conditions for inhibitory synaptic current to induce bursting and spreading depolarization in pyramidal neurons.

ABSTRACT: Enhanced activity of inhibitory neurons, which is often used to suppress behaviors of pyramidal neurons to treat brain diseases, whereas can enhance spiking to a mixed-mode bursting (MMB) in recent experiments on migraine and seizure. The MMB contains a phase with high level of membrane potential/extracellular potassium concentration ([K⁺]_o), which can propagate to form spreading depolarization (SD) wave. Different from the common view that the MMB/SD is often induced by enhanced positive effect or [K⁺]_o, in the present paper, dynamics and conditions for the uncommon MMB/SD evoked by enhanced inhibitory synaptic current are obtained in a theoretical model. Firstly, in addition to the well-known positive threshold across which the common MMB is in

SUBMITTER: Hua H 

PROVIDER: S-EPMC11909148 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature