Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders.

ABSTRACT: Increasing evidence supports the role of the placenta in neurodevelopment and in the onset of neuropsychiatric disorders. Recently, mQTL and iQTL maps have proven useful in understanding relationships between SNPs and GWAS that are not captured by eQTL. In this context, we propose that part of the genetic predisposition to complex neuropsychiatric disorders acts through placental DNA methylation. We construct a public placental cis-mQTL database including 214,830 CpG sites calculated in 368 fetal placenta DNA samples from the INMA project, and run cell type-, gestational age- and sex-imQTL models. We combine these data with summary statistics of GWAS on ten neuropsychiatric disorders using summary-based Mendelian randomization and colocalization. We also evaluate the influence of identifie

SUBMITTER: Cilleros-Portet A 

PROVIDER: S-EPMC11909199 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature