The impact of gamma interferon on BK virus candidate microRNAs and related miRNAs in kidney transplant patients with BK infection.

ABSTRACT: Kidney transplant recipients (KTRs) with impaired immune systems may develop BKV nephropathy (BKVN). BKVN and allograft rejection may harm transplanted kidneys. BKV replicates via miR-B1-5p and 3p in order to escape from host's immunological response. BKV alters KTR and viral gene expression and miRNA profiles. In an inflammatory setting, IFN-γ may initiate the removal of pathogens by inducing an immune response. It has antiviral immunity, which may prevent the virus from replicating by preventing the synthesis of BK virus proteins. Antiviral miRNAs like miR-29a are also produced in response to IFN-γ activation. Thus, we investigated these modifications as putative biomarkers for evaluating viral infection and the regulatory web that arises from their expression during infection and the em

SUBMITTER: Changizi M 

PROVIDER: S-EPMC11909238 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature