Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H₂O₂.

ABSTRACT: Hydrogen peroxide (H₂O₂) is a ubiquitous signal regulating many biological processes, including innate immunity, in all eukaryotes. However, it remains largely unknown that how transcription factors directly sense H₂O₂ in eukaryotes. Here, we report that rice basic/helix-loop-helix transcription factor bHLH25 directly senses H₂O₂ to confer resistance to multiple diseases caused by fungi or bacteria. Upon pathogen attack, rice plants increase the production of H₂O₂, which directly oxidizes bHLH25 at methionine 256 in the nucleus. Oxidized bHLH25 represses miR397b expression to activate lignin biosynthesis for plant cell wall reinforcement, preventing pathogens from penetrating plant cells. Lignin biosynt

SUBMITTER: Liao H 

PROVIDER: S-EPMC11909244 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature