Self-reported myopia and age-related cataract: a two-sample Mendelian randomization study.

ABSTRACT: Our study aims to investigate whether there is evidence for a causal relationship between self-reported myopia and age-related cataract (ARC). A two-sample Mendelian randomization study was performed to identify the causal associations of self-reported myopia with ARC. We used summary-level genetic association data from the MR-Base (Mendelian Randomization-Base) platform on self-reported myopia and ARC. 26 single-nucleotide polymorphisms (SNPs) associated with self-reported myopia were used as instrumental variables. The inverse-variance weighted (IVW) method was applied to perform the primary analysis, and the weighted median method, MR-Egger regression, and Maximum likelihood methods were selected as supplementary analysis. To ensure the reliability of the results, we also performed the

SUBMITTER: Liu H 

PROVIDER: S-EPMC11909268 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature