Clinical evaluation of a polarization-based optical noninvasive glucose sensing system.

ABSTRACT: Diabetes affects millions in the US, causing elevated blood glucose levels that could lead to complications like kidney failure and heart disease. Recent development of continuous glucose monitors has enabled a minimally invasive option, but the discomfort and social factors highlight the need for noninvasive alternatives in diabetes management. We propose a portable noninvasive glucose sensing system based on the glucose's optical activity property which rotates linearly polarized light depending on its concentration level. To enable a portable form factor, a light trap mechanism is used to capture unwanted specular reflection from the palm and the enclosure itself. We fabricate four sensing prototypes and conduct a 363-day multi-session clinical evaluation in real-world settings. 30 part

SUBMITTER: Leung HMC 

PROVIDER: S-EPMC11909277 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature