Angiotensin-Converting Enzyme Inhibition as a Potential Risk Factor for Periprosthetic Joint Infection Following Total Knee Arthroplasty.

ABSTRACT:

Background

Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) portends significant morbidity. In-vivo studies demonstrating angiotensin-converting enzyme inhibitors (ACEis) may have an immunosuppressive effect. This study leveraged a large national registry to test if propensity-matched patients taking ACEis would have higher rates of PJI following TKA than patients taking angiotensin receptor blockers (ARBs).

Methods

A retrospective review of the Mariner PearlDiver database was performed. Patients were divided into those taking either an ACEi or an ARB for 1 year prior to primary TKA. Irrigation and debridement and/or removal of knee prostheses procedural codes were used to identify PJI. Odds ratios (ORs) and 95% confidence intervals (CIs) w

SUBMITTER: Trikha R 

PROVIDER: S-EPMC11909446 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature