Mediating factors in the association between educational attainment and stroke: A mendelian randomization study.

ABSTRACT:

Background

Stroke is a common cardiovascular and cerebrovascular disease with high disability and mortality. Lower educational attainment has been reported to be associated with an increased risk of stroke, but it is unclear which pathways mediate this association.

Methods

Using genome-wide association studies (GWAS) based on European ancestry, we performed two-sample Mendelian randomization (MR) analyses to investigate the causal association of genetically estimated educational attainment with stroke and its subtypes. Then, we used mediation analyses to assess the extent to which seven cardiometabolic risk factors alone and in combination explain their effects.

Results

Genetically estimated educational attainment was negatively associated with the risk of any stroke

SUBMITTER: Xu N 

PROVIDER: S-EPMC11909463 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature