CXCL14 regulates ovarian endometriosis progression by targeting PCNA.

ABSTRACT:

Objective

To explore the regulatory function and mechanism of CXCL14 in endometriosis.

Methods

Quantitative real-time polymerase chain reaction (qRT-PCR) was used to examine the expression of CXCL14 in eutopic and ectopic endometrial stromal cells (ESCs) derived from patients with endometriosis and in situ endometrial stromal cells derived from healthy individuals. Alterations in cell proliferation and migration capabilities were assessed through Cell Counting Kit-8 (CCK8) and transwell assays following the silencing or overexpression of CXCL14. Mass spectrometry was employed to identify potential interacting proteins of CXCL14, and proliferating cell nuclear antigen (PCNA) was selected for further investigation. The regulatory mechanism of PCNA by CXCL14 was further examine

SUBMITTER: Liu M 

PROVIDER: S-EPMC11909536 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature