Comprehensive pan-cancer analysis of LAMA3: implications for prognosis and immunotherapy.

ABSTRACT:

Objectives

Laminin subunit alpha 3 (LAMA3) has been implicated in various cellular processes relevant to cancer progression, including cell proliferation, migration, and adhesion. In this study, we explored the expression, prognostic significance, and functional role of LAMA3 across multiple cancer types.

Methodology

The in silico analyses involve using various bioinformatics tools and databases, such as The Cancer Genome Atlas (TCGA), TIMER2.0, GEPIA2, UALCAN, Kaplan-Meier (KM) plotter, GENT2, Human Protein Atlas (HPA), OncoDB, Gene Set Cancer Analysis (GSCA), and TISIDB. The in vitro analyses include cell culture, gene knockdown, and assays for cell proliferation, colony formation, and wound healing.

Results

Pan-cancer analysis revealed significant variations in LAM

SUBMITTER: Huang H 

PROVIDER: S-EPMC11909552 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature