Preterm birth and risk of bone fractures during childhood and early adulthood.

ABSTRACT: People born preterm have reduced BMD, subnormal peak bone mass, and an increased risk of osteoporosis. Whether this translates to increased risk of bone fractures is uncertain. We assessed fracture risk from childhood to early adulthood in relation to gestational age and sex by conducting a nationwide register-linkage cohort study comprising all 223 615 liveborn (January 1987-September 1990) singletons (9161, 4.1%; preterm) in Finland. Cox regression models provided hazard ratios (HRs) for fracture diagnosis in public specialty health care in both first and recurrent event settings during the whole follow-up (0-29 years) and during different age periods (0-4, 5-9, 10-29 years). Gestational age was considered categorical (full-term, 39-41 weeks; reference). A total of 39 223 (17.5%) childre

SUBMITTER: Alenius S 

PROVIDER: S-EPMC11909738 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature