A Transcriptomic Signature of Depressive Symptoms in Late Life.

ABSTRACT:

Background

Depressive symptoms in late life can impair daily function and accompany cognitive decline. However, the molecular mechanisms that underlie these changes in the brain remain poorly understood.

Methods

Differential expression analysis was performed on bulk-tissue RNA sequencing data generated from dorsolateral prefrontal cortex samples of elderly participants in ROS/MAP (Religious Orders Study and Memory and Aging Project; N = 998, mean age at death = 89.7 years). Bulk tissue RNA sequencing was analyzed against depressive symptoms measured prior to death, controlling for Alzheimer's disease neuropathology, medication status, and lifestyle factors. Sex-stratified models were also tested.

Results

Increased abundance of the Prader-Willi syndrome-associat

SUBMITTER: Matan-Lithwick S 

PROVIDER: S-EPMC11909759 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature