Metabolic Profiling of Individuals with Missing Teeth and Tooth Loss.

ABSTRACT: Missing teeth have been linked to incident cardiovascular disease, diabetes, and all-cause mortality. Our previous study revealed that signs of oral infections and inflammatory conditions (i.e., periodontal disease and dental caries) are associated with disadvantageous features of circulating metabolites. This study investigates whether missing teeth and tooth loss, the end points of these diseases, are associated with similar metabolic features. The 2 Finnish population-based studies Health-2000 (n = 6,197) and FINRISK-97 (n = 6,050) were included, as was Parogene (n = 465), a cohort of patients with an indication for coronary angiography. The number of teeth was recorded in clinical examinations. Serum concentrations of 157 metabolites were determined by a nuclear ma

SUBMITTER: Halme AM 

PROVIDER: S-EPMC11909773 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature