Chewing-Activated TRPV4/PIEZO1-<i>HIF-1α</i>-Zn Axes in a Rat Periodontal Complex.

ABSTRACT: The upstream mechanobiological pathways that regulate the downstream mineralization rates in periodontal tissues are limitedly understood. Herein, we spatially colocalized and correlated compression and tension strain profiles with the expressions of mechanosensory ion channels (MS-ion) TRPV4 and PIEZO1, biometal zinc, mitochondrial function marker (MFN2), cell senescence indicator (p16), and oxygen status marker hypoxia-inducible factor-1α (HIF-1α) in rats fed hard and soft foods. The observed zinc and related cellular homeostasis in vivo were ascertained by TRPV4 and PIEZO1 agonists and antagonists on human periodontal ligament fibroblasts ex vivo. Four-week-old male Sprague-Dawley rats were fed hard (n = 3) or soft (n = 3) foods for 4 wk (in vivo). Sig

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11909774 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature