Physician risk perceptions and surveillance practices for tyrosine kinase inhibitor long-term effects in pediatric CML.

ABSTRACT: Chronic myeloid leukemia (CML) is effectively treated with long-term tyrosine kinase inhibitor (TKI) therapy, yet little is known about risks of prolonged TKI exposure in young patients, and long-term effect monitoring is not standardized. We surveyed North American pediatric oncologists (n = 119) to evaluate perceived risk of and surveillance practices for potential toxicities associated with prolonged TKI exposure in children and adolescents/young adults (AYAs) with CML. Survey domains included general and specific risk perceptions and surveillance practices for asymptomatic patients on chronic TKI therapy. We analyzed data descriptively and explored relationships between risk perceptions and surveillance. Risk perceptions varied among oncologists but were similar across six categories (

SUBMITTER: Smith SM 

PROVIDER: S-EPMC11909793 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature