Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study.

ABSTRACT:

Objective

To evaluate the association between the LHCGR rs2293275 (N312S) genotype and ovarian aging phenotypes in Han Chinese women, focusing on diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI).

Study design

This multicenter population-based study included 1,240 women aged 18-40 years diagnosed with DOR (n = 711) or POI (n = 529), alongside 72,846 ethnically and regionally matched controls from the Han Chinese Genomes Database (PGG.Han). Genotyping of rs2293275 was performed, and clinical data (menstrual history, hormonal profiles, maternal menopause age, and ART outcomes) were analyzed.

Main results

The AA genotype frequency in the ovarian aging cohort (1.85%) was significantly higher than in the general Han population (0.62%, OR 3.04, 95% CI

SUBMITTER: Ma W 

PROVIDER: S-EPMC11909885 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature