Characterization of AI-2/LuxS quorum sensing system in antibiotic resistance, pathogenicity of non carbapenemase-producing carbapenem-resistant Escherichia coli.

ABSTRACT:

Background

As a quorum sensing system, LuxS/AI-2 is closely associated with bacterial growth, biofilm formation, and virulence. As yet, it is not known how the luxS is associated with a diverse array of physiological activities in non- carbapenemase producing carbapenem resistant Escherichia coli (non-CP-CREC). The purpose of this study is to explore the characterization of AI-2/LuxS quorum sensing system in antibiotic resistance, pathogenicity of non-CP-CREC.

Methods

A total of five non-CP-CREC isolates that did not have ompC and ompF deletions were collected from various clinical samples from January 2021 to December 2023. RT-qPCR was used to detect genes expression of luxS, acrA, acrB, tolC, mdtB, mdtC, mdtE, mdtF, ompA, ompX, IL-8, IL-6, and TNF-α. Homologous recombinati

SUBMITTER: Xu X 

PROVIDER: S-EPMC11909908 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature