IFN-γ signaling links ventriculomegaly to choroid plexus and ependyma dysfunction following maternal immune activation.

ABSTRACT: Maternal immune activation (MIA) is a principal environmental risk factor contributing to autism spectrum disorder (ASD) and can be causally linked to ASD symptoms. In our study, we found that MIA triggered by poly (I: C) injection caused ventriculomegaly in offspring due to the dysfunction of the choroid plexus (Chp) and ependyma. We subsequently identified a sustained enhancement of interferon-γ (IFN-γ) signaling in the brain and serum of MIA offspring. Further study revealed that increased IFN-γ signaling could disrupt the barrier function of Chp epithelial cells by activating macrophages, and suppress the differentiation of primary ependymal cells via the signal transducer and activator of transcription 1/3 signaling. The effects of MIA on the offspring were mitigated by administration

SUBMITTER: Sun YQ 

PROVIDER: S-EPMC11909946 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature