Spectroscopic, docking, antiproliferative, and anticancer activity of novel metal derivatives of phenylacetohydrazide Schiff base on different human cancer cell lines.

ABSTRACT: In the last two decades, many Schiff bases have been investigated due to the importance of their metal complexes in the medical field and drug industry. The Schiff base metal complexes have several applications as anticancer agents because they have a high binding ability to nucleic acids (DNA and RNA). The Schiff base H₂L, derived from the condensation of 2-phenylacetohydrazide and 2-hydroxynaphthaldehyde, was reacted with Fe²⁺, Zn²⁺, Cd²⁺, and Pt²⁺ to form the unique metal complexes [Fe(HL)₂], [Zn₂(HL)₂](CH₃COO)₂, [Cd₂(HL)₂](CH₃COO)₂, and [Pt(H₂L)Cl₂]. Various analytical and spectroscopic techniques were used to ch

SUBMITTER: Afifi MA 

PROVIDER: S-EPMC11909975 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature