Modulating the complement system through epitope-specific inhibition by complement C3 inhibitors.

ABSTRACT: As an integral part of the innate immune system, the complement system is a tightly regulated proteolytic cascade, playing a critical role in microbial defense, inflammation activation, and dying host cell clearance. Complement proteins are now emerging as subjects of intense research and drug development, since dysregulation of the complement system plays a critical role in several diseases and disorders, such as paroxysmal nocturnal hemoglobinuria (PNH) and geographic atrophy (GA). Within the complement cascade, complement C3 is the central component, situated at the convergence of all complement activation pathways, rendering it an attractive target for complement-related diseases. However, due to the complicated structure-activity relationship (SAR) of C3, elucidating the mechanisms of

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11910092 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature