Synergistic pathogenicity of novel duck Orthoreovirus and salmonella typhimurium in ducks.

ABSTRACT: Co-infection with Novel Duck Orthoreovirus (N-DRV) and Salmonella Typhimurium (S. Typhimurium) poses significant threats to duck health. The disease associated with N-DRV is characterized by epizootic outbreaks featuring hepatosplenomegaly, hemorrhage, and necrosis. Ducklings infected with STM primarily exhibit symptoms such as fibrinous pericarditis, perihepatitis, and intestinal hemorrhage. In recent years, China has experienced outbreaks involving mixed infections of these two pathogens in various regions, leading to more complex and atypical clinical manifestations. This study investigated the synergistic effects of these pathogens through animal infection models, histopathological analysis, and quantitative PCR. Antimicrobial susceptibility testing confirmed that the isolated S. Typhi

SUBMITTER: Li B 

PROVIDER: S-EPMC11910094 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature