Unraveling the genetic landscape of susceptibility to multiple primary cancers.

ABSTRACT: With advances in cancer screening and treatment, there is a growing population of cancer survivors who may develop subsequent primary cancers. While hereditary cancer syndromes account for only a portion of multiple cancer cases, we sought to explore the role of common genetic variation in susceptibility to multiple primary tumors. We conducted a cross-ancestry genome-wide association study (GWAS) and transcriptome-wide association study (TWAS) of 10,983 individuals with multiple primary cancers, 84,475 individuals with single cancer, and 420,944 cancer-free controls from two large-scale studies. Our GWAS identified six lead variants across five genomic regions that were significantly associated (p < 5 × 10^-8) with the risk of developing multiple primary tumors (overall and inva

SUBMITTER: Middha P 

PROVIDER: S-EPMC11910107 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature