Oxygen tension regulating nanoformulation for the improved photodynamic therapy of hypoxic tumors.

ABSTRACT: The clinical efficacy of photodynamic therapy (PDT) is hampered by the low oxygen tension highly prevalent in solid tumors. Hence, improving the oxygen tension by suppling hyperbaric oxygen (HBO), through oxygen delivery nanoarchitectures or by designing in situ oxygen-generating nanoenzymes is considered a robust approach for PDT that involves type II photosensitizers (PS). In this study, we successfully synthesized 4-arm chlorin-polylactide (CPLA) conjugates from meta-tetra-3-hydroxymethyl phenyl chlorin (m-THMPC) and D, L-lactide via ring opening polymerization (ROP), that could assemble into stable NPs, for the delivery of molecular oxygen into inner regions of hypoxic tumors (HTs). The monodispersed Air-CPLA-NPs prevented the PS, chlorin, from aggregation-i

SUBMITTER: Birhan YS 

PROVIDER: S-EPMC11910142 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature