Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is a systemic autoimmune disease currently with no universally highly effective prevention strategies. Identifying pathogenic immune phenotypes in at-risk populations prior to clinical onset is crucial to establishing effective prevention strategies. Here, we applied multimodal single-cell technologies (mass cytometry and CITE-Seq) to characterize the immunophenotypes in blood from at-risk individuals (ARIs) identified through the presence of serum antibodies against citrullinated protein antigens (ACPAs) and/or first-degree relative (FDR) status, as compared with patients with established RA and people in a healthy control group. We identified significant cell expansions in ARIs compared with controls, including CCR2+CD4+ T cells, T peripheral helper (Tph) cells,

SUBMITTER: Inamo J 

PROVIDER: S-EPMC11910230 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature