A noise-robust post-processing pipeline for accelerated phase-cycled ²³Na Multi-Quantum Coherences MRI.

ABSTRACT:

Purpose

To develop an improved post-processing pipeline for noise-robust accelerated phase-cycled Cartesian Single (SQ) and Triple Quantum (TQ) sodium (²³Na) Magnetic Resonance Imaging (MRI) of in vivo human brain at 7 T.

Theory and methods

Our pipeline aims to tackle the challenges of ²³Na Multi-Quantum Coherences (MQC) MRI including low Signal-to-Noise Ratio (SNR) and time-consuming Radiofrequency (RF) phase-cycling. Our method combines low-rank k-space denoising for SNR enhancement with Dynamic Mode Decomposition (DMD) to robustly separate SQ and TQ signal components. This separation is crucial for computing the TQ/SQ ratio, a key parameter of ²³Na MQC MRI. We validated our pipeline in silico, in vitro and in vivo in healthy volunteers, co

SUBMITTER: Licht C 

PROVIDER: S-EPMC11910250 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature