Distinct sensorimotor cough features in a cohort of Progressive Supranuclear Palsy.

ABSTRACT:

Background

Progressive Supranuclear Palsy (PSP) and Parkinson's disease (PD) similarly affect many neural substrates; however, some brain regions may be more impacted by PSP vs PD, giving rise to distinct cough features that could facilitate earlier differential diagnosis and inform airway protection therapies to prevent fatal lung infections, since patients may not effectively sense and clear irritants from their airways.

Methods

Thirteen individuals with PSP participated and were age- and sex-matched to persons with PD and healthy, unaffected adults. Using a cross-sectional study design this study aimed to 1) compare cough function in PSP using voluntary and induced reflex cough testing, and 2) compare cough airflow and sensation metrics to PD and healthy adult groups.

SUBMITTER: Mir MJ 

PROVIDER: S-EPMC11910345 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature