Autophagy related genes polymorphisms in Parkinson's Disease; A systematic review of literature.

ABSTRACT:

Background

Neurodegenerative diseases are mainly a consequence of degenerated proteins in neurons. Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is characterized by Lewy body deposition. Autophagy is known as one of the cell maintenance mechanisms. Autophagy targets are damaged or degenerated macromolecules and organelles for lysosomal degradation. The role of disrupted autophagy in PD was established earlier. In this regard, the current study aimed to evaluate the frequency and status of the autophagy gene polymorphisms in PD by a systematic review approach.

Materials and methods

In the current study, electronic databases including Scopus, PubMed, and Science Direct were used for the search. The search was performed by using Parkinson's

SUBMITTER: Yousefi P 

PROVIDER: S-EPMC11910361 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature