Metastructure and strain-defect engineered Cu-doped TiO _<i>x</i> coating to enhance antibacterial sonodynamic therapy.

ABSTRACT: Sonodynamic therapy (SDT) has attracted widespread attention in treatment of implant-associated infections, one of the key factors leading to implant failure. Nevertheless, constructing efficient ultrasound-triggered coatings on implant surfaces remains a challenge. Herein, an acoustic metastructure Cu-doped defective titanium oxide coating (Cu-TiO _x ) with lattice strain was constructed in situ on titanium implant to realize effective sonocatalysis. The redistribution of Cu atoms broke the pristine lattice of TiO₂ during the thermal reduction treatment to regulate its energy structure, which favored separation of electron-hole pairs generated by ultrasound radiation to enhance the sonocatalytic generation of reactive oxygen species. In addition, the aco

SUBMITTER: Wang S 

PROVIDER: S-EPMC11910374 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature