Impact of leptin on postoperative peritoneal adhesion formations in colorectal resection.

ABSTRACT:

Purpose

Postoperative peritoneal adhesion formation (PAF) is a distressing complication. Leptin, secreted by fat tissues, may be associated with PAF. However, the relationships between PAF and leptin are unclear. This study investigated the impact of leptin on PAF after colorectal tumor resection.

Methods

A cecum cauterization mouse model was used to investigate PAF and its association with leptin. Mice adhesion score (AS) was evaluated on day 7 after treatment. The clinical study included patients who underwent elective colorectal resection with temporary ileostomy between April 2021 and December 2024. The AS was evaluated at the time of ileostomy closure. Patients with the highest AS quartile were classified into the high-AS group; clinical factors associated with PAF were

SUBMITTER: Maekawa T 

PROVIDER: S-EPMC11910413 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature