Pan-cancer analysis predicts MBOAT2 as a potential new ferroptosis related gene immune checkpoint.

ABSTRACT:

Background

The phospholipid-modifying enzyme MBOAT2 plays a crucial role in iron homeostasis by inhibiting iron sequestration, thus preventing iron-induced cell death. It achieves this by remodeling the phospholipid composition of cell membranes through phospholipid metabolism. Although multiple studies have highlighted the significance of MBOAT2 in tumorigenesis, a comprehensive pan-cancer analysis has not been conducted to date.

Methods

In this study, we analyzed the expression levels of MBOAT2 using RNA sequencing data from the TCGA and GTEx databases. We also investigated MBOAT2 protein information using resources such as the Human Protein Atlas (HPA), GeneCards, and String databases. To assess the prognostic value of MBOAT2, we conducted survival analysis based on clini

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11910489 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature