Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy.

ABSTRACT: Multimodal phototheranostics utilizing single molecules offer a "one-and-done" approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, restricted tumor penetration and retention, and the requirement for multiple irradiations, which significantly constrain their application. In this report, we present an aggregation-induced emission luminogen (AIEgen) bacteria hybrid bionic robot to address above issues. This bionic robot is composed of multifunctional AIEgen (INX-2) and Escherichia coli Nissle 1917 (EcN), i.e., EcN@INX-2. The EcN@INX-2 bionic robot exhibits near-infrared II (NIR-II) fluorescence emission and demonstrates efficient photody

SUBMITTER: Zhu L 

PROVIDER: S-EPMC11910577 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature