Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.

ABSTRACT: Previous studies have demonstrated that silica can activate the NLRP3 inflammasome, and that macrophage phagocytosis is an essential step in this process. Although carbon is the primary component of coal dust particles, it also contains other impurities such as free silica, clay, sulfides, and carbonate minerals. Additional research is still necessary to discover if NLRP3 can be triggered due to the low silica content of coal dust particles. The purpose of this study is to investigate whether coal dust particles can induce the translation and transcription of NLRP3 inflammasome components in rat alveolar macrophages (NR8383) and whether Cytochalasin B may inhibit this process. According to the findings of our research, coal dust particles can upregulate the NLRP3 inflammasome components an

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11910592 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature