Potential locations for non-invasive brain stimulation in treating ADHD: Results from a cross-dataset validation of functional connectivity analysis.

ABSTRACT: Noninvasive brain stimulation (NIBS) has emerged as a promising therapeutic approach for attention-deficit/hyperactivity disorder (ADHD), yet the inaccurate selection of stimulation sites may constrain its efficacy. This study aimed to identify novel NIBS targets for ADHD by integrating meta-analytic findings with cross-dataset validation of functional connectivity patterns. A meta-analysis including 124 functional magnetic resonance imaging (fMRI) studies was first conducted to delineate critical brain regions associated with ADHD, which were defined as regions of interest (ROIs). Subsequently, functional connectivity (FC) analysis was performed using resting-state fMRI data from two independent databases comprising 116 patients with ADHD. Surface brain regions exhibiting consistent FC pa

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11910651 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature